Genetic Disorders in the Growth Hormone – Insulin-Like Growth Factor-I Axis
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چکیده
منابع مشابه
Genetic disorders in the growth hormone - insulin-like growth factor-I axis.
In the last few years, our knowledge of genetically determined causes of short stature has greatly increased by reports of challenging patients, who offered the opportunity to study genes that play a role in growth. Since the first paper that showed the etiology of Laron syndrome [Godowski PJ, et al: Proc Natl Acad Sci USA 1989;86:8083-8087], many mutations in the growth hormone (GH) receptor h...
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The aim of the GH-2000 project is to develop a method for detecting GH doping among athletes. Previous papers in the GH-2000 project have proposed that a forthcoming method to detect GH doping will need specific components from the GH/IGF-I axis and bone markers because these specific variables seem more sensitive to exogenous GH than to exercise. The present study examined the responses of the...
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Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion wi...
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The syndrome of adult GH deficiency and the effects of GH replacement therapy provide a useful model with which to study the effects of the GH/IGF-I axis on exercise physiology. Measures of exercise performance including maximal oxygen uptake and ventilatory threshold are impaired in adult GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delive...
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Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and extreme weight loss, resulting in a body mass index (BMI) of less than 17.5 kg/m2 (American Psychiatric Association [APA], 2000; Dartmouth College Health Services [DCHS], 1999; Eating Disorders Awareness and Prevention [EDAP], Inc., 2000; Stoving et al, 1999). The psychological disturbances behind the disord...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2006
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000095161